Values traced to the European Reference Material ERM-DA470k/IFCC (Institute for Reference Materials and Measurements, IRMM), to ensure lot to lot consistent results.

Particle Enhanced Nephelometric Immunoassay (PENIA), for their use on BN™ and Atellica™ Series nephelometers of Siemens Healthcare.

Kinetic UDR Nephelometric Non-competitive Immunoassay, enhanced with polystyrene particles, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Turbidimetric Immunoassay (TIA), enhanced with polystyrene particles, for their use on Clinical Chemistry automatic analyzers.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Free Light Chains (FLC) (serum and urine)

The measurement of serum FLC levels and the calculation of its ratio (free K/L), as well as the determination of the urinary excretion of monoclonal FLC, have an important clinical significance, both in diagnostic and prognostic terms, in multiple pathological conditions, such as Multiple Myeloma, Waldenström's Macroglobulinemia, AL Amyloidosis, Light chain deposition disease (LCDD) and, in general, in all monoclonal gammopathies. The importance of its determination lies not only in revealing these pathologies but also in its harmful effect on tissues and organs, mainly on the kidney, which is the cause of different clinical manifestations. Periodic quantitative estimation, both in serum and in urine, is also important for monitoring and controlling the evolution of all those pathologies in which FLC are present.

Free Light Chains, FLC, Bence Jones, Multiple Myeloma, MGUS, Amyloidosis, LCDD, Monoclonal Gammopathies, ERM DA470k/IFCC, KLoneus, BN™ BN™, Atellica™ Neph Siemens Healthineers, IMMAGE® Beckman Coulter, PENIA, TIA, NIA.