Standardized to the WHO's International Ref. Preparation for human serum complement Factors (code: W1032).

Nephelometric Immunoassay (NIA) for their use on BN™ Series nephelometers of Siemens Healthcare.

Turbidimetric Immunoassay (TIA), for their use on Clinical Chemistry automatic analyzers.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Complement Factor B

Although Factor B deficiency is rare, when it does occur, it compromises the activation of the complement alternative pathway which is essential in defence against bacterial infections (especially Neisseria).

Reduced levels of Factor B normally indicate activation of the complement alternative pathway. Measurement of FB is helpful when diagnosing certain kinds of kidney diseases (such as chronic glomerulonephritis or lupus nephritis), skin diseases (such as dermatitis herpetiformis or pemphigus vulgaris), rheumatoid arthritis, sickle cell anaemia, as well as certain other infections, such as gram-negative infections.

Factor B, C3PA, Neisseria, Glomerulonephritis, Lupus nephritis, Dermatitis herpetiformis, sickle cell anaemia, Alternative Pathway, WHO code W1032, BN™ Atellica™ Neph Siemens Healthineers, IMMAGE® Beckman Coulter, Optilite® The Binding Site, PENIA, TIA, NIA.