Standardized to the WHO's International Ref. Preparation for human serum complement Factors (code: W1032).

Nephelometric Immunoassay (NIA) for their use on BN™ Series nephelometers of Siemens Healthcare.

Kinetic Non-competitive Nephelometric Immunoassay, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Turbidimetric Immunoassay (TIA), for their use on Clinical Chemistry automatic analyzers.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Complement C5

Deficiency of C5 is associated with increased susceptibility to recurrent severe bacterial infections and has also been linked to susceptibility to autoimmune diseases, such as Systemic Lupus (SLE), Rheumatoid Arthritis or Liver Fibrosis.

Low levels of C5 and normal levels of C3 and C4 are consistent with C5 deficiency, while if reduced levels of C3 and C4 are also found, complement consumption is indicated.

C5, Systemic Lupus (SLE), Rheumatoid Arthritis, Liver Fibrosis, Complement system, WHO code W1032, BN™ Atellica™ Neph Siemens Healthineers, IMMAGE® Beckman Coulter, Optilite® The Binding Site, PENIA, TIA, NIA.