Standardized to the WHO's International Ref. Preparation for human serum complement Factors (code: W1032).

Particle Enhanced Nephelometric Immunoassay (PENIA), for their use on BN™ Series nephelometers of Siemens Healthcare.

Kinetic UDR Non-competitive NIPIA Immunoassay, enhanced with polystyrene particles, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Turbidimetric Immunoassay (TIA), enhanced with polystyrene particles, for their use on Clinical Chemistry automatic analyzers.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Complement C1q

C1q congenital deficiency is extremely rare (a few dozen cases in which the majority of patients suffered from Systemic Lupus (SLE)). Sometimes acquired deficiency is due to the presence of anti-C1q auto-antibodies.

Its deficiency has a significant effect on the host defense mechanisms and in the elimination of immune complexes. It is normally associated with a high incidence of autoimmune and infectious diseases (Systemic Lupus (SLE), Glomerulonephritis, Polymyositis, etc.).

Measurement of C1q is crucial for the differentiation between hereditary or acquired angioedema, because normal levels are found in hereditary angioedema while reduced levels occur in acquired angioedema.

C1q, SLE, Glomerulonephritis, Polymyositis, Hereditary angioedema, Complement system, WHO code W1032, BN™, Atellica™ Neph Siemens Healthineers, IMMAGE® Beckman Coulter, Optilite® The Binding Site, PENIA, TIA, NIA.