Kinetic Immunoassay Non-competitive Nephelometric Assay, for their use on Beckman Coulter's IMMAGE® 800 Immunochemical Systems.

Turbidimetric Immunoassay (TIA) for their use on Clinical Chemistry automatic analyzers.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of the Complement C1 Inhibitor

C1 inhibitor deficiency is associated with hereditary or acquired angioedema. In 85% of cases, levels are reduced (5-30% of their normal value), while the remaining 15% show normal levels but the protein is dysfunctional. The additional measurement of C1q is crucial for the differentiation between hereditary or acquired angioedema, because normal levels are found in hereditary angioedema while reduced levels occur in acquired angioedema.

Low levels of C1 inhibitor also predispose to autoimmune diseases, most markedly Lupus Erythematosus (SLE), due to its consumptive effect on C3 and C4 complement components.

C1 Inhibitor, Complement Esterase Inhibitor, Hereditary or acquired angioedema, Autoimmune diseases, IMMAGE® 800 Beckman Coulter, PENIA, Turbidimetric Immunoassay, TIA.