Turbidimetric Immunoassay (TIA), enhanced with polystyrene particles, for their use on Clinical Chemistry automatic analyzers.

Ready-to-use Reagents, prediluted 6 level Calibrators, and 2 level Controls.

Applications available for the most common analyzers of Clinical Chemistry. For example Advia®, Alinity C, AU®, Atellica™, cobas® C, Optilite® or Mindray among others.

Clinical Significance of Alpha 1 microglobulin

Under normal conditions, in a similar fashion to other micro-proteins, A1m is almost completely reabsorbed by the renal tubules and only a very little amount is excreted in the final urine. Therefore, an increase in urinary concentration is indicative of lesions of the proximal tubule and/or tubular dysfunction. Elevated excretion rates can indicate tubular damage associated with renal tubulointerstitial nephritis or tubular toxicity due to nephrotoxic drug or heavy metal exposure. Glomerulonephropathies and renal vasculopathies also are often associated with coexisting tubular injury and so may result in elevated excretion. Elevated A1m in patients with urinary tract infections may indicate renal involvement (pyelonephritis). A1m is considered a good tubular dysfunction marker due to their quite constant production rates and their stability in urine, even at altered pH.

A test for preeclampsia, where A1m serves as the diagnostic marker, has been proposed. It is based upon the fact that oxidative stress in the placenta tissue triggers the endogenous synthesis and plasma concentration of the protein.

A1m, Preeclampsia, Lesions proximal tubule, tubular dysfunction marker, TIA, Turbidimetric Immunoassay.